Reminiscence therapy is a psychological intervention for older adults to remembering and interpreting life events that were experienced at some time in the past. The purpose of the present study was to investigate the extent of integrative reminiscence intervention effects, with the aim to produce statistically significant reduction in depression symptoms, and significant improvement in psychological well-being, life satisfaction, self esteem, and integrity were examined. Thirty-four healthy elderly participated in the intervention that was implemented in eight sessions. To evaluate the effects of the program, a quasi-experimental design was applied with pretest and posttest evaluations comparing the intervention group with a control group on a waiting list. In comparison to control group, individuals in treatment sample of older adults in an integrative reminiscence group demonstrated statistically significant reduction in depression symptoms and a significant improvement in self-esteem, integrity, life satisfaction, and psychological well-being.