The goal of the current study was to identify aspects of personality that are associated with different ways in which people find meaning in life. This was achieved using constrained principal component analysis (CPCA) on data from 322 university students who completed the Sources of Meaning and Meaning in Life questionnaire and the Big Five Aspects Scale. CPCA demonstrated that personality traits and life meaning are associated but not redundant with one another. Specifically respondents with high scores on lower-level aspects of Openness to Experience tended to derive meaning from questioning learning and challenging tradition whereas those with high scores on aspects of Conscientiousness and Extraversion tended to derive meaning from success at work health and family. Results suggest that personality traits are associated with variations in the domains used to derive meaning in life and demonstrate the utility of CPCA as an innovative statistical technique for the study of individual differences.